The self-assembly of cystine-bridged γ-peptide-based cyclic peptide-dendron hybrids.
Org Biomol Chem
; 11(48): 8443-51, 2013 Dec 28.
Article
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| MEDLINE
| ID: mdl-24202293
ABSTRACT
Novel cystine-bridged γ-peptide-based cyclic peptide-dendron hybrids have been synthesized by oxidative coupling between two cysteine residues of the linear peptides via the formation of disulfide bonds in high yields. The self-assembly of the hybrids was studied by FT-IR, (1)H NMR, TEM, and AFM analyses which indicate that the nanotube was constructed through intermolecular hydrogen-bonding of the hydrophobic cyclic peptide moieties and possesses amphiphilic property by conjugating a hydrophilic dendron on the exterior of the cyclic peptide ring. The diameters of nanofibers that consisted of nanotubes depend on the employed solvent in the self-assembly process, and uniform filaments formed from double amphiphilic nanotubes via hydrophobic interactions between their hydrophobic faces have been observed in water as well as in aqueous solutions.
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MEDLINE
Asunto principal:
Péptidos Cíclicos
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Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
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QUIMICA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China