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A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells.
Oyama, Satomi; Fujino, Hiromichi; Yamazaki, Risa; Okura, Iori; Regan, John W; Awata, Atsuko; Arai, Takayoshi; Murayama, Toshihiko.
Afiliación
  • Oyama S; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
  • Fujino H; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: fujino@p.chiba-u.ac.jp.
  • Yamazaki R; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
  • Okura I; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
  • Regan JW; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ 85721-0207, USA.
  • Awata A; Department of Chemistry, Graduate School of Science, Chiba University, Inage, Chiba 263-8522, Japan.
  • Arai T; Department of Chemistry, Graduate School of Science, Chiba University, Inage, Chiba 263-8522, Japan.
  • Murayama T; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Arch Biochem Biophys ; 541: 21-9, 2014 Jan 01.
Article en En | MEDLINE | ID: mdl-24239863
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Prostaglandina / Receptores Inmunológicos / Prostaglandina D2 / Regulación Neoplásica de la Expresión Génica / Neoplasias del Colon / Antígenos CD55 / Indoles Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Arch Biochem Biophys Año: 2014 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de Prostaglandina / Receptores Inmunológicos / Prostaglandina D2 / Regulación Neoplásica de la Expresión Génica / Neoplasias del Colon / Antígenos CD55 / Indoles Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Arch Biochem Biophys Año: 2014 Tipo del documento: Article País de afiliación: Japón