Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.
Mol Cell Proteomics
; 13(2): 397-406, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24309898
ABSTRACT
Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to â¼80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Especificidad de Órganos
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Expresión Génica
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Genómica
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Proteómica
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Transcriptoma
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Anticuerpos
Límite:
Female
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Humans
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Male
Idioma:
En
Revista:
Mol Cell Proteomics
Asunto de la revista:
BIOLOGIA MOLECULAR
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BIOQUIMICA
Año:
2014
Tipo del documento:
Article