Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats.
Cell Mol Neurobiol
; 34(3): 403-8, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24401942
ABSTRACT
Previous studies in our laboratory have demonstrated that piperine produced antidepressant-like action in various mouse models of behavioral despair, which was related to the serotonergic system. The present study aimed to examine the behavioral and biochemical effects of piperine in rats exposed to chronic unpredictable mild stress (CUMS). The results showed that CUMS caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. In addition, it was found that serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) contents in the hippocampus and frontal cortex were significantly decreased in CUMS-treated rats. Treating the animals with piperine significantly suppressed behavioral and biochemical changes induced by CUMS. The results suggest that piperine produces an antidepressant-like effect in CUMS-treated rats, which is possibly mediated by increasing 5-HT and BDNF contents in selective brain tissues.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piperidinas
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Estrés Psicológico
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Serotonina
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Factor Neurotrófico Derivado del Encéfalo
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Alcaloides
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Benzodioxoles
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Alcamidas Poliinsaturadas
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Antidepresivos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cell Mol Neurobiol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Hong Kong