Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.
Cell
; 50(3): 405-13, 1987 Jul 31.
Article
en En
| MEDLINE
| ID: mdl-2440582
ABSTRACT
The Drosophila Shaker (Sh) gene appears to encode a type of voltage-sensitive potassium (K+) channel called the A channel. We have isolated Sh as part of a 350 kb chromosomal walk. The region around Sh contains four identified transcription units. We find that Sh corresponds to a very large transcription unit encompassing a total of about 95 kb of genomic DNA and split by a major 85 kb intron. Sh has multiple hydrophobic domains that have a high probability of being membrane-spanning, consistent with the proposal that it encodes an ion channel.
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Bases de datos:
MEDLINE
Asunto principal:
Drosophila
/
Genes
/
Canales Iónicos
Idioma:
En
Revista:
Cell
Año:
1987
Tipo del documento:
Article