Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.
Alzheimers Dement
; 11(3): 310-320, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-24418058
ABSTRACT
BACKGROUND:
Gender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown.METHODS:
Prospectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]).RESULTS:
Overall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in women older than 85 years of age. LTR of dementia/AD at age 45 was 1 in 5 in women and 1 in 10 in men. Cardiovascular mortality was higher in men with rate ratios decreasing from approximately 6 at 45 to 54 years of age to less than 2 after age 65.CONCLUSION:
Selective survival of men with a healthier cardiovascular risk profile and hence lower propensity to dementia might partly explain the higher LTR of dementia/AD in women.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Demencia
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Alzheimers Dement
Año:
2015
Tipo del documento:
Article