Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions.

Kang, Wonseok; Sung, Pil Soo; Park, Su-Hyung; Yoon, Sarah; Chang, Dong-Yeop; Kim, Seungtaek; Han, Kwang Hyub; Kim, Ja Kyung; Rehermann, Barbara; Chwae, Yong-Joon; Shin, Eui-Cheol

Kang, Wonseok; Sung, Pil Soo; Park, Su-Hyung; Yoon, Sarah; Chang, Dong-Yeop; Kim, Seungtaek; Han, Kwang Hyub; Kim, Ja Kyung; Rehermann, Barbara; Chwae, Yong-Joon; Shin, Eui-Cheol.

Afiliación

Kang W; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Sung PS; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Park SH; Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.
Yoon S; Department of Microbiology, Ajou University School of Medicine, Suwon, Korea.
Chang DY; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Kim S; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Han KH; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Kim JK; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Rehermann B; Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.
Chwae YJ; Department of Microbiology, Ajou University School of Medicine, Suwon, Korea.
Shin EC; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea. Electronic address: ecshin@kaist.ac.kr.

Gastroenterology ; 146(5): 1351-60.e1-4, 2014 May.

Article en En | MEDLINE | ID: mdl-24486950

Asunto(s)

Inmunidad Adaptativa; Linfocitos T CD8-positivos/inmunología; Hepacivirus/inmunología; Hepatocitos/inmunología; Antígenos de Histocompatibilidad Clase I/metabolismo; Interferones/metabolismo; Linfocitos T CD8-positivos/metabolismo; Linfocitos T CD8-positivos/virología; Línea Celular Tumoral; Técnicas de Cocultivo; Replicación del ADN; ADN Viral/biosíntesis; Regulación hacia Abajo; Activación Enzimática; Factor 2 Eucariótico de Iniciación/metabolismo; Genotipo; Hepacivirus/genética; Hepacivirus/crecimiento & desarrollo; Hepacivirus/metabolismo; Hepacivirus/patogenicidad; Hepatocitos/metabolismo; Hepatocitos/virología; Antígenos de Histocompatibilidad Clase I/genética; Interacciones Huésped-Patógeno; Humanos; Fosforilación; Interferencia de ARN; Transducción de Señal; Transfección; eIF-2 Quinasa/genética; eIF-2 Quinasa/metabolismo

Palabras clave

Adaptive Immune Response; Antigen Presentation; Immune Evasion; JFH-1

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Antígenos de Histocompatibilidad Clase I / Interferones / Hepacivirus / Linfocitos T CD8-positivos / Hepatocitos / Inmunidad Adaptativa Límite: Humans Idioma: En Revista: Gastroenterology Año: 2014 Tipo del documento: Article

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