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Pathogens and host immunity in the ancient human oral cavity.
Warinner, Christina; Rodrigues, João F Matias; Vyas, Rounak; Trachsel, Christian; Shved, Natallia; Grossmann, Jonas; Radini, Anita; Hancock, Y; Tito, Raul Y; Fiddyment, Sarah; Speller, Camilla; Hendy, Jessica; Charlton, Sophy; Luder, Hans Ulrich; Salazar-García, Domingo C; Eppler, Elisabeth; Seiler, Roger; Hansen, Lars H; Castruita, José Alfredo Samaniego; Barkow-Oesterreicher, Simon; Teoh, Kai Yik; Kelstrup, Christian D; Olsen, Jesper V; Nanni, Paolo; Kawai, Toshihisa; Willerslev, Eske; von Mering, Christian; Lewis, Cecil M; Collins, Matthew J; Gilbert, M Thomas P; Rühli, Frank; Cappellini, Enrico.
Afiliación
  • Warinner C; 1] Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland. [2] Department of Anthropology, University of Oklahoma, Norman, Oklahoma, USA.
  • Rodrigues JF; 1] Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland. [2] Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Vyas R; 1] Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland. [2] Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Trachsel C; Functional Genomics Center Zürich, University of Zürich/Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.
  • Shved N; Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland.
  • Grossmann J; Functional Genomics Center Zürich, University of Zürich/Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.
  • Radini A; 1] BioArCh, Department of Archaeology, University of York, York, UK. [2] University of Leicester Archaeological Services (ULAS), School of Archaeology and Ancient History, University of Leicester, Leicester, UK.
  • Hancock Y; Department of Physics, University of York, York, UK.
  • Tito RY; Department of Anthropology, University of Oklahoma, Norman, Oklahoma, USA.
  • Fiddyment S; BioArCh, Department of Archaeology, University of York, York, UK.
  • Speller C; BioArCh, Department of Archaeology, University of York, York, UK.
  • Hendy J; BioArCh, Department of Archaeology, University of York, York, UK.
  • Charlton S; BioArCh, Department of Archaeology, University of York, York, UK.
  • Luder HU; Centre of Dental Medicine, Institute of Oral Biology, University of Zürich, Zürich, Switzerland.
  • Salazar-García DC; 1] Research Group on Plant Foods in Hominin Dietary Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. [2] Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. [3] Department of Prehistory and Archaeology, University of Vale
  • Eppler E; 1] Research Group Neuro-Endocrine-Immune Interactions, Institute of Anatomy, University of Zürich, Zürich, Switzerland. [2] Zürich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
  • Seiler R; Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland.
  • Hansen LH; 1] Department of Biology, Microbiology, University of Copenhagen, Copenhagen, Denmark. [2] Department of Environmental Science, Aarhus Universitet, Roskilde, Denmark.
  • Castruita JA; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
  • Barkow-Oesterreicher S; Functional Genomics Center Zürich, University of Zürich/Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.
  • Teoh KY; BioArCh, Department of Archaeology, University of York, York, UK.
  • Kelstrup CD; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Olsen JV; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Nanni P; Functional Genomics Center Zürich, University of Zürich/Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland.
  • Kawai T; 1] Department of Immunology and Infectious Diseases, Forsyth Institute, Cambridge, Massachusetts, USA. [2] Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, Massachusetts, USA.
  • Willerslev E; Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark.
  • von Mering C; 1] Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland. [2] Swiss Institute of Bioinformatics, Lausanne, Switzerland.
  • Lewis CM; Department of Anthropology, University of Oklahoma, Norman, Oklahoma, USA.
  • Collins MJ; BioArCh, Department of Archaeology, University of York, York, UK.
  • Gilbert MT; 1] Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark. [2] Ancient DNA Laboratory, Murdoch University, Perth, Western Australia, Australia.
  • Rühli F; 1] Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland. [2].
  • Cappellini E; 1] Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark. [2].
Nat Genet ; 46(4): 336-44, 2014 Apr.
Article en En | MEDLINE | ID: mdl-24562188
ABSTRACT
Calcified dental plaque (dental calculus) preserves for millennia and entraps biomolecules from all domains of life and viruses. We report the first, to our knowledge, high-resolution taxonomic and protein functional characterization of the ancient oral microbiome and demonstrate that the oral cavity has long served as a reservoir for bacteria implicated in both local and systemic disease. We characterize (i) the ancient oral microbiome in a diseased state, (ii) 40 opportunistic pathogens, (iii) ancient human-associated putative antibiotic resistance genes, (iv) a genome reconstruction of the periodontal pathogen Tannerella forsythia, (v) 239 bacterial and 43 human proteins, allowing confirmation of a long-term association between host immune factors, 'red complex' pathogens and periodontal disease, and (vi) DNA sequences matching dietary sources. Directly datable and nearly ubiquitous, dental calculus permits the simultaneous investigation of pathogen activity, host immunity and diet, thereby extending direct investigation of common diseases into the human evolutionary past.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cálculos Dentales / Genoma Bacteriano / Proteoma / Bacteroidetes / Microbiota / Boca Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cálculos Dentales / Genoma Bacteriano / Proteoma / Bacteroidetes / Microbiota / Boca Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos