Phosphate homeostasis and disorders.
Ann Clin Biochem
; 51(Pt 6): 631-56, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-24585932
ABSTRACT
Recent studies of inherited disorders of phosphate metabolism have shed new light on the understanding of phosphate metabolism. Phosphate has important functions in the body and several mechanisms have evolved to regulate phosphate balance including vitamin D, parathyroid hormone and phosphatonins such as fibroblast growth factor-23 (FGF23). Disorders of phosphate homeostasis leading to hypo- and hyperphosphataemia are common and have clinical and biochemical consequences. Notably, recent studies have linked hyperphosphataemia with an increased risk of cardiovascular disease. This review outlines the recent advances in the understanding of phosphate homeostasis and describes the causes, investigation and management of hypo- and hyperphosphataemia.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fosfatos
/
Hiperfosfatemia
/
Hipofosfatasia
Límite:
Humans
Idioma:
En
Revista:
Ann Clin Biochem
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido