Cathepsin C inhibitors: property optimization and identification of a clinical candidate.
J Med Chem
; 57(6): 2357-67, 2014 Mar 27.
Article
en En
| MEDLINE
| ID: mdl-24592859
ABSTRACT
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores de Proteasas
/
Catepsina C
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Suecia