Risk of fracture in patients with Charcot-Marie-Tooth disease.
Muscle Nerve
; 50(6): 919-24, 2014 Dec.
Article
en En
| MEDLINE
| ID: mdl-24634316
ABSTRACT
INTRODUCTION:
In this study we evaluated fracture risk in patients with Charcot-Marie-Tooth (CMT) disease.METHODS:
We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987-2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures.RESULTS:
The risk of non-osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01-2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98-1.74) and AHR 1.10 (95% CI 0.69-1.74), respectively].CONCLUSIONS:
CMT patients have a 1.5-fold increased risk for non-osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Enfermedad de Charcot-Marie-Tooth
/
Fracturas Óseas
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Muscle Nerve
Año:
2014
Tipo del documento:
Article
País de afiliación:
Países Bajos