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Metabolic syndrome across Europe: different clusters of risk factors.
Scuteri, Angelo; Laurent, Stephane; Cucca, Francesco; Cockcroft, John; Cunha, Pedro Guimaraes; Mañas, Leocadio Rodriguez; Mattace Raso, Francesco U; Muiesan, Maria Lorenza; Ryliskyte, Ligita; Rietzschel, Ernst; Strait, James; Vlachopoulos, Charalambos; Völzke, Henry; Lakatta, Edward G; Nilsson, Peter M.
Afiliación
  • Scuteri A; San Raffaele Pisana IRCCS, Rome, Italy angeloelefante@interfree.it.
  • Laurent S; INSERM U970, Paris, France University Paris Descartes, Paris, France.
  • Cucca F; Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
  • Cockcroft J; Cardiff University, Cardiff, UK.
  • Cunha PG; Centro Hospitalar do Alto Ave/Minho University. Guimaraes Braga, Portugal.
  • Mañas LR; Hospital Universitario de Getafe, Madrid, Spain.
  • Mattace Raso FU; Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Muiesan ML; Università di Brescia, Brescia, Italy 2° Medicina Generale Spedali Civili, Brescia, Italy.
  • Ryliskyte L; Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
  • Rietzschel E; Ghent University Hospital and Ghent University, Ghent, Belgium.
  • Strait J; National Institutes of Health, Baltimore, USA.
  • Vlachopoulos C; Athens Medical School, Athens, Greece.
  • Völzke H; University Medicine Greifswald, Germany.
  • Lakatta EG; National Institutes of Health, Baltimore, USA.
  • Nilsson PM; Lund University, Malmö, Sweden.
Eur J Prev Cardiol ; 22(4): 486-91, 2015 Apr.
Article en En | MEDLINE | ID: mdl-24647805
ABSTRACT

BACKGROUND:

Metabolic syndrome (MetS) remains a controversial entity. Specific clusters of MetS components - rather than MetS per se - are associated with accelerated arterial ageing and with cardiovascular (CV) events. To investigate whether the distribution of clusters of MetS components differed cross-culturally, we studied 34,821 subjects from 12 cohorts from 10 European countries and one cohort from the USA in the MARE (Metabolic syndrome and Arteries REsearch) Consortium.

METHODS:

In accordance with the ATP III criteria, MetS was defined as an alteration three or more of the following five components elevated glucose (G), fasting glucose ≥110 mg/dl; low HDL cholesterol, < 40mg/dl for men or <50 mg/dl for women; high triglycerides (T), ≥150 mg/dl; elevated blood pressure (B), ≥130/≥85 mmHg; abdominal obesity (W), waist circumference >102 cm for men or >88 cm for women.

RESULTS:

MetS had a 24.3% prevalence (8468

subjects:

23.9% in men vs. 24.6% in women, p < 0.001) with an age-associated increase in its prevalence in all the cohorts. The age-adjusted prevalence of the clusters of MetS components previously associated with greater arterial and CV burden differed across countries (p < 0.0001) and in men and women (p < 0.0001). In details, the cluster TBW was observed in 12% of the subjects with MetS, but was far more common in the cohorts from the UK (32.3%), Sardinia in Italy (19.6%), and Germany (18.5%) and less prevalent in the cohorts from Sweden (1.2%), Spain (2.6%), and the USA (2.5%). The cluster GBW accounted for 12.7% of subjects with MetS with higher occurrence in Southern Europe (Italy, Spain, and Portugal 31.4, 18.4, and 17.1% respectively) and in Belgium (20.4%), than in Northern Europe (Germany, Sweden, and Lithuania 7.6, 9.4, and 9.6% respectively).

CONCLUSIONS:

The analysis of the distribution of MetS suggested that what follows under the common definition of MetS is not a unique entity rather a constellation of cluster of MetS components, likely selectively risky for CV disease, whose occurrence differs across countries.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Síndrome Metabólico Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Límite: Aged80 País/Región como asunto: America do norte / Europa Idioma: En Revista: Eur J Prev Cardiol Año: 2015 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Síndrome Metabólico Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Límite: Aged80 País/Región como asunto: America do norte / Europa Idioma: En Revista: Eur J Prev Cardiol Año: 2015 Tipo del documento: Article País de afiliación: Italia