Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells.

Alli, Abdel A; Brewer, Elizabeth M; Montgomery, Darrice S; Ghant, Marcus S; Eaton, Douglas C; Brown, Lou Ann; Helms, My N

Alli, Abdel A; Brewer, Elizabeth M; Montgomery, Darrice S; Ghant, Marcus S; Eaton, Douglas C; Brown, Lou Ann; Helms, My N.

Afiliación

Alli AA; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia;
Brewer EM; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; and.
Montgomery DS; Department of Biological Sciences, Clark Atlanta University, Atlanta, Georgia.
Ghant MS; Department of Biological Sciences, Clark Atlanta University, Atlanta, Georgia.
Eaton DC; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; and.
Brown LA; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; and.
Helms MN; Department of Physiology, Emory University School of Medicine, Atlanta, Georgia; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia; and mhelms@emory.edu.

Am J Physiol Lung Cell Mol Physiol ; 306(11): L1026-35, 2014 Jun 01.

Article en En | MEDLINE | ID: mdl-24682449

Asunto(s)

Células Epiteliales Alveolares/metabolismo; Depresores del Sistema Nervioso Central/toxicidad; Etanol/toxicidad; Mitocondrias/metabolismo; Proteoma/metabolismo; Alcoholismo; Células Epiteliales Alveolares/efectos de los fármacos; Animales; Células Cultivadas; Femenino; Lipopolisacáridos/farmacología; Pulmón/efectos de los fármacos; Pulmón/patología; Masculino; Potencial de la Membrana Mitocondrial; Ratones; Ratones Endogámicos C57BL; Microscopía Electrónica de Transmisión; Mitocondrias/efectos de los fármacos; Mitocondrias/patología; Dilatación Mitocondrial; Análisis de Secuencia por Matrices de Oligonucleótidos; Proteoma/genética; Ratas; Ratas Sprague-Dawley; Transcriptoma/efectos de los fármacos

Palabras clave

ENaC; chronic alcohol ingestion; gene chip array; mass spectrometry; mitochondrial stress

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Depresores del Sistema Nervioso Central / Proteoma / Etanol / Células Epiteliales Alveolares / Mitocondrias Límite: Animals Idioma: En Revista: Am J Physiol Lung Cell Mol Physiol Asunto de la revista: BIOLOGIA MOLECULAR / FISIOLOGIA Año: 2014 Tipo del documento: Article

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