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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Fares, Mohamed-Bilal; Ait-Bouziad, Nadine; Dikiy, Igor; Mbefo, Martial K; Jovicic, Ana; Kiely, Aoife; Holton, Janice L; Lee, Seung-Jae; Gitler, Aaron D; Eliezer, David; Lashuel, Hilal A.
Afiliación
  • Fares MB; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland.
  • Ait-Bouziad N; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland.
  • Dikiy I; Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY 10065, USA.
  • Mbefo MK; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland.
  • Jovicic A; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Kiely A; Queen Square Brain Bank, UCL Institute of Neurology, London, UK.
  • Holton JL; Queen Square Brain Bank, UCL Institute of Neurology, London, UK.
  • Lee SJ; Department of Biomedical Science and Technology, Konkuk University, Seoul, South Korea.
  • Gitler AD; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Eliezer D; Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY 10065, USA.
  • Lashuel HA; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Ecole Polytechnique Fédérale de Lausanne, Station 19, CH-1015 Lausanne, Switzerland hilal.lashuel@epfl.ch.
Hum Mol Genet ; 23(17): 4491-509, 2014 Sep 01.
Article en En | MEDLINE | ID: mdl-24728187
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Membrana Celular / Núcleo Celular / Alfa-Sinucleína / Agregación Patológica de Proteínas / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Suiza
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Membrana Celular / Núcleo Celular / Alfa-Sinucleína / Agregación Patológica de Proteínas / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2014 Tipo del documento: Article País de afiliación: Suiza