Coexpression of cytokeratins and vimentin in normal and diseased thyroid glands. Lack of diagnostic utility of vimentin immunostaining.
Am J Surg Pathol
; 13(12): 1034-40, 1989 Dec.
Article
en En
| MEDLINE
| ID: mdl-2480720
ABSTRACT
We documented the coexpression of cytokeratins and vimentin in epithelial cells of the thyroid gland in 100 samples examined from 65 patients. These included normal, inflammatory, and neoplastic tissues that were routinely fixed in formalin and embedded in paraffin. The number of epithelial cells coexpressing the two intermediate filament proteins as well as the subcellular compartmentalization of vimentin immunoreactivity did not correlate with the various conditions of the thyroid gland. Therefore, we conclude that the immunolocalization of vimentin does not represent a useful adjunct tool for the histopathological diagnosis of thyroid diseases.
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Bases de datos:
MEDLINE
Asunto principal:
Enfermedades de la Tiroides
/
Glándula Tiroides
/
Vimentina
/
Queratinas
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Surg Pathol
Año:
1989
Tipo del documento:
Article
País de afiliación:
Italia