Relationship between alcohol dependence and the DBI rs2276596 (C/A) polymorphism in Japanese.
Nihon Arukoru Yakubutsu Igakkai Zasshi
; 49(1): 39-44, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-24818357
ABSTRACT
To facilitate elucidation of the pathogenesis of alcohol dependence, we investigated the relationship between a genetic variant of diazepam biding inhibitor (DBI) C/A polymorphism (rs2276596) and alcohol dependence. We determined the DBI genotypes using a novel method involving PCR-RFLP in healthy controls and alcoholics with a diagnosis of alcohol dependence by ICD-10 (F10.20). There was a significant difference in the rs2276596 polymorphism C/A allele frequency of the DBI gene (P < 0.0001) between alcoholics and healthy controls. The present data suggested that a mutant allele of the DBI was one of the risk factors for alcohol dependence as for the rs2276596 polymorphism.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Inhibidor de la Unión a Diazepam
/
Alcoholismo
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Nihon Arukoru Yakubutsu Igakkai Zasshi
Asunto de la revista:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Año:
2014
Tipo del documento:
Article