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A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases.
Staderini, Matteo; Aulic, Suzana; Bartolini, Manuela; Tran, Hoang Ngoc Ai; González-Ruiz, Víctor; Pérez, Daniel I; Cabezas, Nieves; Martínez, Ana; Martín, M Antonia; Andrisano, Vincenza; Legname, Giuseppe; Menéndez, J Carlos; Bolognesi, Maria Laura.
Afiliación
  • Staderini M; Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
  • Aulic S; SISSA, Neuroscience Department, Via Bonomea 265, 34136 Trieste, Italy.
  • Bartolini M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
  • Tran HN; SISSA, Neuroscience Department, Via Bonomea 265, 34136 Trieste, Italy.
  • González-Ruiz V; Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
  • Pérez DI; Instituto de Química Médica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
  • Cabezas N; Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
  • Martínez A; Instituto de Química Médica-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
  • Martín MA; Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
  • Andrisano V; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
  • Legname G; SISSA, Neuroscience Department, Via Bonomea 265, 34136 Trieste, Italy.
  • Menéndez JC; Departamento de Química Orgánica y Farmacéutica and Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense , 28040 Madrid, Spain.
  • Bolognesi ML; Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy.
ACS Med Chem Lett ; 4(2): 225-9, 2013 Feb 14.
Article en En | MEDLINE | ID: mdl-24900645
ABSTRACT
(E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aß and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aß self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test).
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: ACS Med Chem Lett Año: 2013 Tipo del documento: Article País de afiliación: España
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: ACS Med Chem Lett Año: 2013 Tipo del documento: Article País de afiliación: España