Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer: a Danish population-based cohort study.
BMJ Open
; 4(6): e005082, 2014 Jun 05.
Article
en En
| MEDLINE
| ID: mdl-24902734
ABSTRACT
OBJECTIVES:
To assess the interaction between comorbidity and breast cancer (BC) on the rate of venous thromboembolism (VTE) beyond what can be explained by the independent effects of BC and comorbidity.DESIGN:
Population-based matched cohort study.SETTING:
Denmark.PARTICIPANTS:
Danish patients with BC (n=62â 376) diagnosed in 1995-2010 and a comparison cohort of women without BC (n=304â 803) from the general population were matched to the patients with BC on year of birth in 5-year intervals and on the specific diseases included in the Charlson Comorbidity Index (CCI) and atrial fibrillation and obesity.MEASURES:
The rate ratios of VTE per 1000 person-years (PY) were computed by comorbidity levels using the CCI, and interaction contrasts (IC) were calculated as a measure of the excess or deficit VTE rate not explained by the independent effects of BC and comorbidity.RESULTS:
Among patients with BC with a CCI score of 1, the 0-1â year VTE rate was 12/1000 PY, and interaction accounted for 10% of the rate (IC=3.2, 95% CI 0.5 to 5.9). Among patients with BC with CCI ≥4, the VTE rate was 17, and interaction accounted for 8% of the rate (IC=1.2, 95% CI -1.8 to 4.2). There was no interaction during 2-5â years of follow-up.CONCLUSIONS:
There was only little interaction between BC and the CCI score on the rate of VTE.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Tromboembolia Venosa
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
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Child
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Child, preschool
/
Female
/
Humans
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Infant
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
BMJ Open
Año:
2014
Tipo del documento:
Article
País de afiliación:
Dinamarca