Effect of lactation on maternal postpartum cardiac function and adiposity: a murine model.
Am J Obstet Gynecol
; 211(4): 424.e1-7, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-24905416
ABSTRACT
OBJECTIVE:
Lactation is associated with reduction in maternal metabolic disease and hypertension later in life; however, findings in humans may be confounded by socioeconomic factors. We sought to determine the independent contribution of lactation on cardiovascular parameters and adiposity in a murine model. STUDYDESIGN:
Following delivery, CD-1 female mice were randomly divided into 2 groups lactated (L; nursed pups for 3 weeks, n = 10), and nonlactated (NL; pups were removed after birth, n = 12). Blood pressure (BP) was assessed prepregnancy and at 1 and 2 months' postpartum. Visceral and subcutaneous adipose tissue determined by computed tomography and left ventricular ejection fraction, cardiac output, and the E/A ratio determined by microultrasound were evaluated at 1 and 2 months' postpartum. The results were analyzed using a Student t test (significance at P < .05).RESULTS:
We observed a significantly different maternal BP at 2 months' postpartum with relatively greater BP in NL (systolic BP NL, 122.2 ± 7.2 vs L, 96.8 ± 9.8 mm Hg; P = .04; diastolic BP NL, 87.0 ± 6.8 vs L, 65.9 ± 6.2 mm Hg; P = .04). Visceral adipose tissue was significantly increased in NL mice at 1 (22.0 ± 4.1% vs 10.7 ± 1.8%, P = .04) and 2 months' postpartum (22.9 ± 3.5% vs 11.2 ± 2.2%, P = .02), whereas subcutaneous adipose tissue did not differ between the groups. At 2 months' postpartum, ejection fraction (51.8 ± 1.5% vs 60.5 ± 3.8%; P = .04), cardiac output (14.2 ± 1.0 vs 18.0 ± 1.3 mL/min; P = .02) and mitral valve E/A ratio (1.38 ± 0.06 vs 1.82 ± 0.13; P = .04) were significantly lower in NL mice than L mice.CONCLUSION:
Our data provide evidence that interruption of lactation adversely affects postpartum maternal cardiovascular function and adiposity.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Lactancia
/
Función Ventricular Izquierda
/
Adiposidad
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Am J Obstet Gynecol
Año:
2014
Tipo del documento:
Article