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Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
Mimura, Naoya; Hideshima, Teru; Shimomura, Toshiyasu; Suzuki, Rikio; Ohguchi, Hiroto; Rizq, Ola; Kikuchi, Shohei; Yoshida, Yasuhiro; Cottini, Francesca; Jakubikova, Jana; Cirstea, Diana; Gorgun, Gullu; Minami, Jiro; Tai, Yu-Tzu; Richardson, Paul G; Utsugi, Teruhiro; Iwama, Atsushi; Anderson, Kenneth C.
Afiliación
  • Mimura N; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Hideshima T; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Shimomura T; Tsukuba Research Center, TAIHO Pharmaceutical Co., Ltd., Tsukuba, Japan.
  • Suzuki R; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Ohguchi H; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Rizq O; Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Kikuchi S; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Yoshida Y; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Cottini F; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Jakubikova J; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Cirstea D; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Gorgun G; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Minami J; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Tai YT; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Richardson PG; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
  • Utsugi T; Tsukuba Research Center, TAIHO Pharmaceutical Co., Ltd., Tsukuba, Japan.
  • Iwama A; Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Anderson KC; Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. kenneth_anderson@dfci.harvard.edu.
Cancer Res ; 74(16): 4458-69, 2014 Aug 15.
Article en En | MEDLINE | ID: mdl-24934808
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Estrés del Retículo Endoplásmico / Inhibidores de Proteasoma / Compuestos Heterocíclicos con 3 Anillos / Mieloma Múltiple Límite: Animals / Humans Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas c-akt / Estrés del Retículo Endoplásmico / Inhibidores de Proteasoma / Compuestos Heterocíclicos con 3 Anillos / Mieloma Múltiple Límite: Animals / Humans Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article País de afiliación: Japón