Long-term durable response to lenalidomide in a patient with hepatic epithelioid hemangioendothelioma.
World J Gastroenterol
; 20(22): 7049-54, 2014 Jun 14.
Article
en En
| MEDLINE
| ID: mdl-24944501
ABSTRACT
Epithelioid hemangioendothelioma (EH) is a rare tumor arising from the vascular endothelial cells of soft tissue or visceral organs. The most common visceral site is the liver, where it is often involved in a multifocal manner known as hepatic EH (HEH). Surgical resection with curative intent represents the gold standard therapy. When surgery is not feasible, or in cases of metastatic disease, no standard medical treatment is currently indicated. In small series, drugs with anti-angiogenic activity (such as bevacizumab, sorafenib, thalidomide, and lenalidomide) have been proposed with promising results. We describe a 73-year-old man with multifocal non-resectable HEH treated with lenalidomide. Disease status was evaluated by abdominal ultrasound and magnetic resonance every four months. The patient was treated for a total of 39 mo with prolonged disease stabilization and, at the time of writing, is still under treatment with a good tolerance profile. During a short period of treatment discontinuation, the disease showed slight progression that immediately resolved after the reintroduction of lenalidomide. Lenalidomide may represent a valid treatment option for HEH due to its anti-angiogenic and antineoplastic activities. This preliminary result merits further study in a large series.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Talidomida
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Hemangioendotelioma Epitelioide
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Inhibidores de la Angiogénesis
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Neoplasias Hepáticas
Límite:
Aged
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Humans
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Male
Idioma:
En
Revista:
World J Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia