Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis.

Agalave, Nilesh M; Larsson, Max; Abdelmoaty, Sally; Su, Jie; Baharpoor, Azar; Lundbäck, Peter; Palmblad, Karin; Andersson, Ulf; Harris, Helena; Svensson, Camilla I

Agalave, Nilesh M; Larsson, Max; Abdelmoaty, Sally; Su, Jie; Baharpoor, Azar; Lundbäck, Peter; Palmblad, Karin; Andersson, Ulf; Harris, Helena; Svensson, Camilla I.

Afiliación

Agalave NM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden Department of Medicine, Karolinska Institutet, Stockholm, Sweden Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Pain ; 155(9): 1802-1813, 2014 Sep.

Article en En | MEDLINE | ID: mdl-24954167

Asunto(s)

Artritis Experimental/metabolismo; Proteína HMGB1/metabolismo; Hiperalgesia/metabolismo; Neuroglía/metabolismo; Médula Espinal/metabolismo; Receptor Toll-Like 4/metabolismo; Animales; Artritis Experimental/fisiopatología; Conducta Animal/fisiología; Femenino; Hiperalgesia/fisiopatología; Masculino; Ratones; Médula Espinal/fisiopatología

Palabras clave

Cytokine; HMGB1; Hypersensitivity; Inflammation; Pain; Rheumatoid arthritis; Spinal cord; TLR4

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Artritis Experimental / Médula Espinal / Neuroglía / Proteína HMGB1 / Receptor Toll-Like 4 / Hiperalgesia Límite: Animals Idioma: En Revista: Pain Año: 2014 Tipo del documento: Article País de afiliación: Suecia

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