Nocapyrones: α- and γ-pyrones from a marine-derived Nocardiopsis sp.
Mar Drugs
; 12(7): 4110-25, 2014 Jul 08.
Article
en En
| MEDLINE
| ID: mdl-25007160
ABSTRACT
One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the α-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 23 enantiomeric mixture of (R)- and (S)-isomers.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pironas
/
Actinobacteria
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón