Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.

Zhong, Yu; Morris, Deanna H; Jin, Lin; Patel, Mittul S; Karunakaran, Senthil K; Fu, You-Jun; Matuszak, Emily A; Weiss, Heidi L; Chait, Brian T; Wang, Qing Jun

Zhong, Yu; Morris, Deanna H; Jin, Lin; Patel, Mittul S; Karunakaran, Senthil K; Fu, You-Jun; Matuszak, Emily A; Weiss, Heidi L; Chait, Brian T; Wang, Qing Jun.

Afiliación

Zhong Y; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536.
Morris DH; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536.
Jin L; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536.
Patel MS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536.
Karunakaran SK; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536.
Fu YJ; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536.
Matuszak EA; Graduate Center for Toxicology, and University of Kentucky, Lexington, Kentucky 40536.
Weiss HL; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536 and.
Chait BT; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, New York, New York, 10065.
Wang QJ; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536; Graduate Center for Toxicology, and University of Kentucky, Lexington, Kentucky 40536; Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536 and. Electronic address: qingjun.wang@u

J Biol Chem ; 289(38): 26021-26037, 2014 Sep 19.

Article en En | MEDLINE | ID: mdl-25086043

Asunto(s)

Proteínas Adaptadoras del Transporte Vesicular/metabolismo; Proteínas Reguladoras de la Apoptosis/metabolismo; Autofagia; Fosfatidilinositol 3-Quinasas Clase III/metabolismo; Proteínas de la Membrana/metabolismo; Fosfatos de Fosfatidilinositol/metabolismo; Transactivadores/fisiología; Secuencia de Aminoácidos; Proteínas Relacionadas con la Autofagia; Beclina-1; Proteínas Fluorescentes Verdes/biosíntesis; Células Hep G2; Humanos; Datos de Secuencia Molecular; Complejos Multiproteicos/metabolismo; Fagosomas/metabolismo; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; Mapas de Interacción de Proteínas; Transporte de Proteínas; Proteínas Recombinantes de Fusión/biosíntesis; Transactivadores/química

Palabras clave

Autophagosome Biogenesis; Autophagy; Beclin 1; Cellular Regulation; Nrbf2; Protein Degradation; Protein-Protein Interaction; Subcellular Organelle; Vps34

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Autofagia / Transactivadores / Fosfatos de Fosfatidilinositol / Proteínas Adaptadoras del Transporte Vesicular / Proteínas Reguladoras de la Apoptosis / Fosfatidilinositol 3-Quinasas Clase III / Proteínas de la Membrana Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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