The risk of high-grade squamous intraepithelial lesions in women with low serum levels of vitamin A.
Gynecol Obstet Invest
; 78(4): 235-8, 2014.
Article
en En
| MEDLINE
| ID: mdl-25171088
ABSTRACT
BACKGROUND:
The progression of the cervical squamous intraepithelial lesion (SIL) is associated with many cofactors, and nutritional aspects are gradually assuming an important role in understanding the physiopathogenesis.OBJECTIVE:
To assess the serum levels of retinol in women from a poor region of Brazil with a histological diagnosis of cervical high-grade SIL (HSIL).METHODS:
A cross-sectional study was conducted in 62 women aged 14-48 years who had a cervical biopsy and were treated at the Federal University of Ceara in Fortaleza, Brazil. Serum retinol levels were measured in peripheral blood by a spectrophotometry technique. Values were categorized as subnormal (<20 µg/dl) or normal (≥20 µg/dl). Multivariate logistic regression was used to determine the association between serum levels of retinol and HSIL for a confidence interval of 95%.RESULTS:
Twenty-six out of 62 women (42%) had a negative histopathological result for SIL and 36 (58%) were diagnosed with SIL (20 low SIL and 16 high SIL). The level of retinol was more frequently low in women with HSIL, but there was no statistical significance [p = 0.409, OR 2.26 (0.33-15.59)].CONCLUSION:
There was no association between high SIL and low levels of retinol in peripheral blood.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vitamina A
/
Deficiencia de Vitamina A
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Neoplasias del Cuello Uterino
/
Lesiones Intraepiteliales Escamosas de Cuello Uterino
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Gynecol Obstet Invest
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil