Increase in H-Y antigen-positive lymphocytes in hirsute women: effects of cyproterone acetate and estradiol treatment.
J Clin Endocrinol Metab
; 68(1): 58-62, 1989 Jan.
Article
en En
| MEDLINE
| ID: mdl-2521223
To investigate a possible relationship between lymphocyte H-Y antigen expression and plasma androgen concentrations in hirsute women, 27 hirsute women were studied. A significant increase in the percentage of H-Y-positive lymphocytes was found in both hirsute women with idiopathic hirsutism [13.4 +/- 2.9% (+/- SD); n = 15] and hirsute women with the polycystic ovary syndrome (13.0 +/- 2.8%; n = 12) compared to that in normal women (10.0 +/- 1.9%; n = 30; P less than 0.0005). Plasma testosterone and androstenedione concentrations, % H-Y+ lymphocytes, and hirsutism scores diminished during oral cyproterone acetate (50 mg/day) and percutaneous estradiol (3 mg/day) treatment. Significant correlations between % H-Y+ lymphocytes and hirsutism scores (P less than 0.001), % H-Y+ lymphocytes and plasma T concentrations (P less than 0.01) were found. We conclude that 1) women can produce H-Y antigen in the same way as men; 2) hirsutism is associated with an increase in H-Y antigen; and 3) the antiandrogen cyproterone acetate reduces H-Y antigen expression on lymphocytes.
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Bases de datos:
MEDLINE
Asunto principal:
Linfocitos
/
Antígeno H-Y
/
Ciproterona
/
Estradiol
/
Hirsutismo
Límite:
Adult
/
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
1989
Tipo del documento:
Article
País de afiliación:
Francia