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FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.
Vogel, Marion J; Xie, Linka; Guan, Hanfeng; Tooze, Reuben M; Maier, Thomas; Kostezka, Ulrike; Maier, Harald J; Holzmann, Karlheinz; Chan, Fong Chun; Steidl, Christian; Reichel, Jonathan B; Weitzer, Clarissa D; Gehringer, Franziska; Kick, Anita B; Cesarman, Ethel; Roshal, Mikhail; Gascoyne, Randy D; Möller, Peter; Wirth, Thomas; Ushmorov, Alexey.
Afiliación
  • Vogel MJ; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Xie L; Cancer Center of Union Hospital and.
  • Guan H; Department of Orthopaedic Surgery, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, China;
  • Tooze RM; Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom; Haematological Malignancy Diagnostic Service, Leeds Teaching Hospitals National Health Service Trust, St. James's University Hospital, Leeds, United Kingdom;
  • Maier T; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Kostezka U; Department of Pathology and.
  • Maier HJ; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Holzmann K; Genomics Core Facility, University of Ulm, Ulm, Germany;
  • Chan FC; Department of Pathology and Laboratory Medicine, Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics, Vancouver, Canada;
  • Steidl C; Department of Pathology and Laboratory Medicine, Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics, Vancouver, Canada;
  • Reichel JB; Tri-Institutional Training Program in Computational Biology and Medicine and.
  • Weitzer CD; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Gehringer F; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Kick AB; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Cesarman E; Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; and.
  • Roshal M; Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; and Memorial Sloan-Kettering Cancer Center, New York, NY.
  • Gascoyne RD; Department of Pathology and Laboratory Medicine, Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics, Vancouver, Canada;
  • Möller P; Department of Pathology and.
  • Wirth T; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
  • Ushmorov A; Institute of Physiological Chemistry, University of Ulm, Ulm, Germany;
Blood ; 124(20): 3118-29, 2014 Nov 13.
Article en En | MEDLINE | ID: mdl-25232062
The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-κB, JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma cell (PC) differentiation PRDM1/BLIMP-1, levels of PRDM1 remain low in cHL. FOXO1, playing a critical role in normal B-cell development, acts as a tumor suppressor in cHL, but has never been associated with induction of PC differentiation. Here we show that FOXO1 directly upregulates the full-length isoform PRDM1α in cHL cell lines. We also observed a positive correlation between FOXO1 and PRDM1 expression levels in primary Hodgkin-Reed-Sternberg cells. Further, we show that PRDM1α acts as a tumor suppressor in cHL at least partially by blocking MYC. Here we provide a link between FOXO1 repression and PRDM1α downregulation in cHL and identify PRDM1α as a tumor suppressor in cHL. The data support a potential role for FOXO transcription factors in normal PC differentiation.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Plasmáticas / Proteínas Represoras / Enfermedad de Hodgkin / Regulación Neoplásica de la Expresión Génica / Factores de Transcripción Forkhead Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Blood Año: 2014 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Plasmáticas / Proteínas Represoras / Enfermedad de Hodgkin / Regulación Neoplásica de la Expresión Génica / Factores de Transcripción Forkhead Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Blood Año: 2014 Tipo del documento: Article