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Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8.
Yamazaki, Yohko; Someno, Tetsuya; Igarashi, Masayuki; Kinoshita, Naoko; Hatano, Masaki; Kawada, Manabu; Momose, Isao; Nomoto, Akio.
Afiliación
  • Yamazaki Y; Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
  • Someno T; Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
  • Igarashi M; Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
  • Kinoshita N; Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
  • Hatano M; Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
  • Kawada M; Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
  • Momose I; Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
  • Nomoto A; 1] Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan [2] Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
J Antibiot (Tokyo) ; 68(4): 279-85, 2015 Apr.
Article en En | MEDLINE | ID: mdl-25269460
ABSTRACT
Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Streptomyces / Antagonistas de Receptores Androgénicos / Antineoplásicos Límite: Humans / Male Idioma: En Revista: J Antibiot (Tokyo) Año: 2015 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Streptomyces / Antagonistas de Receptores Androgénicos / Antineoplásicos Límite: Humans / Male Idioma: En Revista: J Antibiot (Tokyo) Año: 2015 Tipo del documento: Article País de afiliación: Japón