Anti-viral tetris: modulation of the innate anti-viral immune response by A20.
Adv Exp Med Biol
; 809: 49-64, 2014.
Article
en En
| MEDLINE
| ID: mdl-25302365
ABSTRACT
The A20 protein has emerged as an important negative regulator of Toll like receptor (TLR) and retinoic acid-inducible gene 1 (RIG-I)-mediated anti-viral signaling. A20 functions both as a RING-type E3 ubiquitin ligase and as a de-ubiquitinating enzyme. Nuclear factor kappa B (NF-kappaB) and interferon regulatory factor (IRF) pathways are targeted by A20 through mechanisms that appear to be both overlapping and distinct, resulting in the downregulation of interferon alpha/beta (IFNalpha/beta) production. This review specifically details the impact of A20 on the cytosolic RIG-I/MDA5 pathway, a process that is less understood than that of NF-kappaB but is essential for the regulation of the innate immune response to viral infection.
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Bases de datos:
MEDLINE
Asunto principal:
Virus
/
Proteínas Nucleares
/
Péptidos y Proteínas de Señalización Intracelular
/
Proteínas de Unión al ADN
/
Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
2014
Tipo del documento:
Article