Malaria control and elimination, Venezuela, 1800s ­1970s.

Venezuela had the highest number of human malaria cases in Latin American before 1936. During 1891­1920,malaria was endemic to >600,000 km2 of this country; malaria death rates led to major population decreases during 1891­1920. No pathogen, including the influenza virus that caused the 1918 pandemic, caused more deaths than malaria during 1905­1945. Early reports of malaria eradication in Venezuela helped spark the world's interest in global eradication. We describe early approaches to malaria epidemiology in Venezuela and how this country developed an efficient control program and an approach to eradication.Arnoldo Gabaldón was a key policy maker during this development process. He directed malaria control in Venezuela from the late 1930s to the end of the 1970s and contributed to malaria program planning of the World Health Organization.We discuss how his efforts helped reduce the incidence of malaria in Venezuela and how his approach diverged from World Health Organization guidelines.