Blood-brain barrier dysfunction, seizures and epilepsy.
Semin Cell Dev Biol
; 38: 26-34, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25444846
ABSTRACT
The blood-brain barrier (BBB) is a dynamic and complex system which separates the brain from the blood. It helps to maintain the homeostasis of the brain, which is essential for normal neuronal functioning. BBB function is impaired in several neurological diseases, including epilepsy in which it may lead to abnormal and excessive neuronal firing. In this review we will discuss how BBB dysfunction can affect neuronal function and how this can lead to seizures and epilepsy. We will also summarize new therapies that aim to preserve or restore BBB function in order to prevent or reduce epileptogenesis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Barrera Hematoencefálica
/
Epilepsia
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Semin Cell Dev Biol
Asunto de la revista:
EMBRIOLOGIA
Año:
2015
Tipo del documento:
Article