Lithocarpic acids O-S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus.
Bioorg Med Chem Lett
; 24(23): 5395-8, 2014 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-25453795
ABSTRACT
Chemical investigation of the cupules of Lithocarpus polystachyus resulted in the identification of four 3,4-seco-homo-cycloartane and one homo-cycloartane derivatives named lithocarpic acids O-S. Their structures were determined based on extensive 1D/2D NMR, IR, MS spectroscopic analyses and chemical methods. Lithocarpic acid O (1) exhibited inhibitory activities on mouse and human isozymes of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) with IC50 values of 0.49 and 1.1 µM, respectively.
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Bases de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Extractos Vegetales
/
Fagaceae
/
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2014
Tipo del documento:
Article