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Using a PyMOL activity to reinforce the connection between genotype and phenotype in an undergraduate genetics laboratory.
Simmons, Alexandra D; Nguyen, Thao K T; Follis, Jack L; Ribes-Zamora, Albert.
Afiliación
  • Simmons AD; Department of Biology, University of Saint Thomas, 3800 Montrose Boulevard, Houston, Texas 770066-4626, United States of America.
  • Nguyen TK; Department of Biology, University of Saint Thomas, 3800 Montrose Boulevard, Houston, Texas 770066-4626, United States of America.
  • Follis JL; Department of Mathematics, Computer Science and Cooperative Engineering, University of Saint Thomas, 3800 Montrose Boulevard, Houston, Texas 770066-4626, United States of America.
  • Ribes-Zamora A; Department of Biology, University of Saint Thomas, 3800 Montrose Boulevard, Houston, Texas 770066-4626, United States of America.
PLoS One ; 9(12): e114257, 2014.
Article en En | MEDLINE | ID: mdl-25461967
With the purpose of developing an activity that would help clarify genetic concepts related to the connection between genotype and phenotype and the nature of mutations, we designed a three hour teaching module using the PyMol software. The activity starts with two pre-laboratory assignments, one to learn how to use PyMol and the other to read about a specific protein or protein family. During the laboratory students are given instructions where and how to find additional information on a specific disease and its causal mutations in order to prepare a 10-minute, in-class presentation. Using a post activity, anonymous quiz, we found a statistically significant different grade distribution in students that participated in the PyMol activity relative to a control group. We also found a significant improvement in the student's comprehension when answering questions regarding the nature of mutations and protein structure. This demonstrates the utility of this simulation activity as a vehicle to improve student's understanding of specific key genetic concepts.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenotipo / Genética / Genotipo Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fenotipo / Genética / Genotipo Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos