Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Bisson, Joseph A; Mills, Bradley; Paul Helt, Jay-Christian; Zwaka, Thomas P; Cohen, Ethan David

Bisson, Joseph A; Mills, Bradley; Paul Helt, Jay-Christian; Zwaka, Thomas P; Cohen, Ethan David.

Afiliación

Bisson JA; Division of Endocrinology and Metabolism, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Mills B; Division of Endocrinology and Metabolism, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Paul Helt JC; Division of Endocrinology and Metabolism, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Zwaka TP; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Cohen ED; Division of Endocrinology and Metabolism, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA; Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address: Ethan_Cohen@URMC.Rochester.edu.

Dev Biol ; 398(1): 80-96, 2015 Feb 01.

Article en En | MEDLINE | ID: mdl-25482987

Asunto(s)

Regulación del Desarrollo de la Expresión Génica; Corazón/embriología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Células Madre/citología; Proteínas Wnt/metabolismo; Vía de Señalización Wnt/fisiología; Animales; Caspasas/metabolismo; Línea Celular; Células Madre Embrionarias/citología; Femenino; Masculino; Ratones; Ratones Transgénicos; Mutación; Miocardio/citología; Fosforilación; Reacción en Cadena de la Polimerasa; Embarazo; Preñez; Transducción de Señal; Proteína Wnt-5a

Palabras clave

Akt; Cardiac progenitor cell; Caspase; Heart; Wnt signaling; ß-Catenin

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre / Regulación del Desarrollo de la Expresión Génica / Proteínas Proto-Oncogénicas c-akt / Proteínas Wnt / Vía de Señalización Wnt / Corazón Límite: Animals / Pregnancy Idioma: En Revista: Dev Biol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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