[Molecular biology for sarcoma: useful or necessary?]. / Biologie moléculaire en pathologie des tissus mous : utile ou nécessaire ?
Ann Pathol
; 35(1): 107-13, 2015 Jan.
Article
en Fr
| MEDLINE
| ID: mdl-25533919
ABSTRACT
Sarcomas are a heterogeneous group of tumors. Their diagnosis is based on morphology and immunohistochemical profile, with categories of tumors according to the type of tissue that they resemble. Nevertheless, for several tumors, cellular origin is unknown. Molecular analysis performed in recent years allowed, combining histophenotype and genomics, better classifying such sarcomas, individualizing new entities and grouping some tumors. Simple and recurrent genetic alterations, such as translocation, mutation, amplification, can be identified in one of two sarcomas and appear as new diagnostic markers. Their identification in specialized laboratories in molecular pathology of sarcomas is often useful and sometimes necessary for a good diagnosis, leading to a heavy and multidisciplinary multi-step treatment.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Neoplasias de los Tejidos Blandos
/
Neoplasias Óseas
/
Técnicas de Diagnóstico Molecular
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
Fr
Revista:
Ann Pathol
Año:
2015
Tipo del documento:
Article