Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.

Moon, Mi Jin; Lee, Yoo-Na; Park, Sumi; Reyes-Alcaraz, Arfaxad; Hwang, Jong-Ik; Millar, Robert Peter; Choe, Han; Seong, Jae Young

Moon, Mi Jin; Lee, Yoo-Na; Park, Sumi; Reyes-Alcaraz, Arfaxad; Hwang, Jong-Ik; Millar, Robert Peter; Choe, Han; Seong, Jae Young.

Afiliación

Moon MJ; From the Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea.
Lee YN; From the Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea.
Park S; From the Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea.
Reyes-Alcaraz A; From the Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea.
Hwang JI; From the Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea.
Millar RP; Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria 0028, Medical Research Council Receptor Biology Unit, and University of Cape Town, Cape Town 7925, South Africa, and Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH164TJ, Scotla
Choe H; Department of Physiology and Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Seoul 138-736, Korea hchoe@ulsan.ac.kr.
Seong JY; From the Graduate School of Medicine, Korea University, Seoul 136-705, Republic of Korea, jyseong@korea.ac.kr.

J Biol Chem ; 290(9): 5696-706, 2015 Feb 27.

Article en En | MEDLINE | ID: mdl-25561730

Asunto(s)

Aminoácidos/química; Péptido 1 Similar al Glucagón/química; Estructura Terciaria de Proteína; Receptores de Glucagón/química; Secuencia de Aminoácidos; Aminoácidos/genética; Aminoácidos/metabolismo; Sitios de Unión/genética; Secuencia Conservada/genética; Evolución Molecular; Péptido 1 Similar al Glucagón/genética; Péptido 1 Similar al Glucagón/metabolismo; Receptor del Péptido 1 Similar al Glucagón; Células HEK293; Humanos; Ligandos; Modelos Moleculares; Datos de Secuencia Molecular; Péptidos/química; Péptidos/genética; Péptidos/metabolismo; Mutación Puntual; Unión Proteica; Receptores de Glucagón/genética; Receptores de Glucagón/metabolismo; Homología de Secuencia de Aminoácido

Palabras clave

Diabetes; Evolution; G Protein-coupled Receptor (GPCR); GLP-1; GLP1R; Ligand Selectivity; Molecular Modeling; Signaling

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estructura Terciaria de Proteína / Receptores de Glucagón / Péptido 1 Similar al Glucagón / Aminoácidos Límite: Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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