Changes in serum trough levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn's disease.

Steenholdt, Casper; Bendtzen, Klaus; Brynskov, Jørn; Thomsen, Ole Ø; Munck, Lars K; Christensen, Lisbet A; Pedersen, Gitte; Kjeldsen, Jens; Ainsworth, Mark A

Steenholdt, Casper; Bendtzen, Klaus; Brynskov, Jørn; Thomsen, Ole Ø; Munck, Lars K; Christensen, Lisbet A; Pedersen, Gitte; Kjeldsen, Jens; Ainsworth, Mark A.

Afiliación

Steenholdt C; Department of Gastroenterology, Herlev Hospital, Herlev, Denmark steenholdt@brygge.dk.
Bendtzen K; Institute for Inflammation Research, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.
Brynskov J; Department of Gastroenterology, Herlev Hospital, Herlev, Denmark.
Thomsen OØ; Department of Gastroenterology, Herlev Hospital, Herlev, Denmark.
Munck LK; Department of Medical Gastroenterology, Køge Hospital, Køge, Denmark.
Christensen LA; Department of Hepatology and Gastroenterology V, Aarhus Hospital, Aarhus, Denmark.
Pedersen G; Department of Gastroenterology, Hvidovre Hospital, Hvidovre Denmark.
Kjeldsen J; Department of Medical Gastroenterology S, Odense Hospital, Odense, Denmark.
Ainsworth MA; Department of Gastroenterology, Herlev Hospital, Herlev, Denmark.

J Crohns Colitis ; 9(3): 238-45, 2015 Mar.

Article en En | MEDLINE | ID: mdl-25576753

Asunto(s)

Anticuerpos/sangre; Enfermedad de Crohn/tratamiento farmacológico; Fármacos Gastrointestinales/farmacocinética; Infliximab/farmacocinética; Adolescente; Adulto; Enfermedad de Crohn/sangre; Enfermedad de Crohn/inmunología; Relación Dosis-Respuesta a Droga; Esquema de Medicación; Monitoreo de Drogas; Femenino; Fármacos Gastrointestinales/sangre; Fármacos Gastrointestinales/inmunología; Fármacos Gastrointestinales/uso terapéutico; Humanos; Infliximab/sangre; Infliximab/inmunología; Infliximab/uso terapéutico; Modelos Lineales; Masculino; Estudios Prospectivos; Curva ROC; Insuficiencia del Tratamiento; Adulto Joven

Palabras clave

IBD; antibodies against IFX; dose intensification; dose optimization; infliximab; loss of response; therapeutic drug monitoring

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fármacos Gastrointestinales / Enfermedad de Crohn / Infliximab / Anticuerpos Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: J Crohns Colitis Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Dinamarca

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