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Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.
Onorato, Joelle M; Chu, Ching-Hsuen; Ma, Zhengping; Kopcho, Lisa M; Chao, Hannguang J; Lawrence, R Michael; Cheng, Dong.
Afiliación
  • Onorato JM; Departments of Bioanalytical and Discovery Analytical Science, Bristol-Myers Squibb Company, Princeton, NJ.
  • Chu CH; Fibrosis Discovery, Bristol-Myers Squibb Company, Princeton, NJ.
  • Ma Z; Fibrosis Discovery, Bristol-Myers Squibb Company, Princeton, NJ.
  • Kopcho LM; Mechanistic Biochemistry, Bristol-Myers Squibb Company, Princeton, NJ.
  • Chao HJ; Discovery Chemistry, Research and Development, Bristol-Myers Squibb Company, Princeton, NJ.
  • Lawrence RM; Discovery Chemistry, Research and Development, Bristol-Myers Squibb Company, Princeton, NJ.
  • Cheng D; Fibrosis Discovery, Bristol-Myers Squibb Company, Princeton, NJ. Electronic address: dong.cheng@bms.com.
J Lipid Res ; 56(3): 747-753, 2015 Mar.
Article en En | MEDLINE | ID: mdl-25598079
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bioensayo / N-Acetilglucosaminiltransferasas / Diglicéridos / Inhibidores Enzimáticos Límite: Animals / Humans Idioma: En Revista: J Lipid Res Año: 2015 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bioensayo / N-Acetilglucosaminiltransferasas / Diglicéridos / Inhibidores Enzimáticos Límite: Animals / Humans Idioma: En Revista: J Lipid Res Año: 2015 Tipo del documento: Article