High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition.
J Pediatr Gastroenterol Nutr
; 61(1): 138-43, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-25633498
ABSTRACT
OBJECTIVES:
Ready-to-use therapeutic food (RUTF) is the preferred treatment for uncomplicated severe acute malnutrition. It contains large amounts of linoleic acid and little α-linolenic acid, which may reduce the availability of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) to the recovering child. A novel high-oleic RUTF (HO-RUTF) was developed with less linoleic acid to determine its effect on DHA and EPA status.METHODS:
We conducted a prospective, randomized, double-blind clinical effectiveness trial treating rural Malawian children with severe acute malnutrition. Children were treated with either HO-RUTF or standard RUTF. Plasma phospholipid fatty acid status was measured on enrollment and after 4 weeks and compared between the 2 intervention groups.RESULTS:
Among the 141 children enrolled, 48 of 71 receiving HO-RUTF and 50 of 70 receiving RUTF recovered. Plasma phospholipid samples were analyzed from 43 children consuming HO-RUTF and 35 children consuming RUTF. The change in DHA content during the first 4 weeks was +4% and -25% in the HO-RUTF and RUTF groups, respectively (Pâ=â0.04). For EPA, the change in content was 63% and -24% in the HO-RUTF and RUTF groups, respectively (Pâ<â0.001). For arachidonic acid, the change in content was -3% and 13% in the HO-RUTF and RUTF groups, respectively (Pâ<â0.009).CONCLUSIONS:
The changes in DHA and EPA seen in the children treated with HO-RUTF warrant further investigation because they suggest that HO-RUTF support improved polyunsaturated fatty acid status, necessary for neural development and recovery.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Alimentos Formulados
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Ácidos Docosahexaenoicos
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Estado Nutricional
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Desnutrición Proteico-Calórica
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Ácido Oléico
Tipo de estudio:
Clinical_trials
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Observational_studies
Límite:
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2015
Tipo del documento:
Article