Serum brain-derived neurotropic factor level predicts adverse clinical outcomes in patients with heart failure.
J Card Fail
; 21(4): 300-6, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25639689
ABSTRACT
BACKGROUND:
Brain-derived neurotropic factor (BDNF) is involved in cardiovascular diseases as well as skeletal muscle energy metabolism and depression. We investigated whether serum BDNF level was associated with prognosis in patients with heart failure (HF). METHODS ANDRESULTS:
We measured the serum BDNF level in 58 patients with HF (59.2 ± 13.7 years old, New York Heart Association functional class I-III) at baseline, and adverse events, including all cardiac deaths and HF rehospitalizations, were recorded during the median follow-up of 20.3 months. In a univariate analysis, serum BDNF levels were significantly associated with peak oxygen capacity (ß = 0.547; P = .003), anaerobic threshold (ß = 0.929; P = .004), and log minute ventilation/carbon dioxide production slope (ß = -10.15; P = .005), but not Patient Health Questionnaire scores (ß = -0.099; P = .586). A multivariate analysis demonstrated that serum BDNF level was an independent prognostic factor of adverse events (hazard ratio 0.41, 95% confidence interval 0.20-0.84; P = .003). The receiver operating characteristic curve demonstrated that low levels of BDNF (<17.4 ng/mL) were associated with higher rates of adverse events compared with high levels of BDNF (≥17.4 ng/mL; log rank test P < .001).CONCLUSIONS:
Decreased serum BDNF levels were significantly associated with adverse outcomes in HF patients, suggesting that these levels can be a useful prognostic biomarker.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
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Factor Neurotrófico Derivado del Encéfalo
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Insuficiencia Cardíaca
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Card Fail
Asunto de la revista:
CARDIOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón