AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells.

Park, Yong H; Mueller, Brett H; McGrady, Nolan R; Ma, Hai-Ying; Yorio, Thomas

Park, Yong H; Mueller, Brett H; McGrady, Nolan R; Ma, Hai-Ying; Yorio, Thomas.

Afiliación

Park YH; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA. Electronic address: ypark@live.unthsc.edu.
Mueller BH; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
McGrady NR; Department of Cell Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX, USA; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Ma HY; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA.
Yorio T; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, USA. Electronic address: thomas.yorio@unthsc.edu.

Exp Eye Res ; 132: 136-50, 2015 Mar.

Article en En | MEDLINE | ID: mdl-25643624

Asunto(s)

Receptores AMPA/fisiología; Células Ganglionares de la Retina/metabolismo; Animales; Proteína de Unión a CREB/metabolismo; Caspasas/metabolismo; Células Cultivadas; Agonistas de Aminoácidos Excitadores/farmacología; Sistema de Señalización de MAP Quinasas/fisiología; Masculino; Proteína Quinasa 1 Activada por Mitógenos/metabolismo; Proteína Quinasa 3 Activada por Mitógenos/metabolismo; Modelos Animales; Ratas; Ratas Sprague-Dawley; Receptores AMPA/agonistas; Receptores AMPA/metabolismo; Células Ganglionares de la Retina/efectos de los fármacos; Ácido alfa-Amino-3-hidroxi-5-metil-4-isoxazol Propiónico/farmacología

Palabras clave

AMPA receptor; Desensitization; Excitotoxicity; Primary retinal ganglion cells; cAMP response element-binding protein

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Ganglionares de la Retina / Receptores AMPA Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Exp Eye Res Año: 2015 Tipo del documento: Article

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