Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.

Chen, L; Chen, W; Mysliwski, M; Serio, J; Ropa, J; Abulwerdi, F A; Chan, R J; Patel, J P; Tallman, M S; Paietta, E; Melnick, A; Levine, R L; Abdel-Wahab, O; Nikolovska-Coleska, Z; Muntean, A G

Chen, L; Chen, W; Mysliwski, M; Serio, J; Ropa, J; Abulwerdi, F A; Chan, R J; Patel, J P; Tallman, M S; Paietta, E; Melnick, A; Levine, R L; Abdel-Wahab, O; Nikolovska-Coleska, Z; Muntean, A G.

Afiliación

Chen L; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Chen W; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Mysliwski M; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Serio J; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Ropa J; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Abulwerdi FA; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Interdepartmental Program in Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Chan RJ; 1] Herman B Wells Center for Pediatric Research, Department of Medical and Molecular Genetics, University School of Medicine, Indianapolis, IN, USA [2] Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Patel JP; Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Tallman MS; Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Paietta E; Montefiore Medical Center-North Division, Immunology Laboratory, Cancer Center, Bronx, NY, USA.
Melnick A; 1] Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA [2] Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.
Levine RL; Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Abdel-Wahab O; Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Nikolovska-Coleska Z; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Muntean AG; 1] Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA [2] Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Leukemia ; 29(6): 1290-300, 2015 Jun.

Article en En | MEDLINE | ID: mdl-25650089

Asunto(s)

Resistencia a Antineoplásicos/genética; Interleucina-3/farmacología; Leucemia Mieloide Aguda/tratamiento farmacológico; Mutación/genética; Proteína 1 de la Secuencia de Leucemia de Células Mieloides/antagonistas & inhibidores; Células Madre Neoplásicas/patología; Proteína Tirosina Fosfatasa no Receptora Tipo 11/genética; Animales; Apoptosis; Proteínas Reguladoras de la Apoptosis; Western Blotting; Proliferación Celular; Ensayos Clínicos Fase III como Asunto; Femenino; Humanos; Leucemia Mieloide Aguda/genética; Leucemia Mieloide Aguda/patología; Ratones; Ratones Endogámicos C57BL; Proteína 1 de la Secuencia de Leucemia de Células Mieloides/genética; Proteína 1 de la Secuencia de Leucemia de Células Mieloides/metabolismo; Células Madre Neoplásicas/efectos de los fármacos; Proteínas de Fusión Oncogénica/genética; Proteínas de Fusión Oncogénica/metabolismo; ARN Mensajero/genética; ARN Interferente Pequeño/genética; Reacción en Cadena en Tiempo Real de la Polimerasa; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Células Tumorales Cultivadas

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Leucemia Mieloide Aguda / Interleucina-3 / Resistencia a Antineoplásicos / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Proteína 1 de la Secuencia de Leucemia de Células Mieloides / Mutación Tipo de estudio: Diagnostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Leukemia Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google