Interferon beta 1a-induced severe autoimmune hepatitis in patients with multiple sclerosis: report of two cases and review of the literature.
Ann Hepatol
; 14(2): 273-80, 2015.
Article
en En
| MEDLINE
| ID: mdl-25671839
ABSTRACT
Type I interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The development of autoimmune hepatitis is a well recognized complication of treatment with alpha IFN in patients with chronic viral hepatitis. Yet, the occurrence in patients under treatment with beta IFN for other indications is controversial and its occurrence often underestimated. We report two cases of severe acute autoimmune hepatitis in two patients undergoing therapy with IFN beta 1a for multiple sclerosis who recovered under early immunosuppressive therapy.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Interferón beta
/
Hepatitis Autoinmune
/
Esclerosis Múltiple Recurrente-Remitente
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Factores Inmunológicos
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Argentina