Metal-free synthesis of indole via NIS-mediated cascade C-N bond formation/aromatization.

ABSTRACT

A novel rapid synthesis of indoles from N-Ts-2-alkenylanilines has been described; the reaction involves a NIS-mediated cascade C-N bond formation/aromatization, and a series of indoles with various functional groups have been synthesized in good to excellent yields under mild conditions without any other additives or catalysts.