Diagnostic challenges during pretreatment long-term follow-up in a patient with FIP1L1-PDGFRA-positive eosinophilia.
Intern Med
; 54(6): 637-42, 2015.
Article
en En
| MEDLINE
| ID: mdl-25786456
ABSTRACT
Obtaining a precise characterization of eosinophilia is crucial, as successful treatment relies on the underlying etiology of the disease. Platelet-derived growth factor receptor alpha-related disorders were first specified in 2008 as a distinct group of clonal eosinophilic disorders with exceptional responsiveness to imatinib. We herein present the case of a man with myeloid neoplasm and eosinophilia in whom a definitive diagnosis could not be adequately made based on histopathological features who was ultimately diagnosed only after extensive molecular analyses and successfully treated with imatinib. In addition, we discuss the diagnostic and therapeutic approaches to treating patients presenting with eosinophilia.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piperazinas
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Pirimidinas
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Benzamidas
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Leucemia Mieloide
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Proteínas de Fusión Oncogénica
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Receptor alfa de Factor de Crecimiento Derivado de Plaquetas
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Factores de Escisión y Poliadenilación de ARNm
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Eosinofilia
/
Antineoplásicos
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Intern Med
Asunto de la revista:
MEDICINA INTERNA
Año:
2015
Tipo del documento:
Article