Photophobia in primary headaches.
Headache
; 55(4): 600-4, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25790126
ABSTRACT
BACKGROUND:
Photophobia is a debilitating feature of many headache disorders. OVERVIEW Clinical and preclinical research has identified several potential pathways involved in enhanced light sensitivity. Some of these structures include trigeminal afferents in the eye, second-order neurons in the trigeminal nucleus caudalis, third-order neurons in the posterior thalamus, modulatory neurons in the hypothalamus, and fourth-order neurons in the visual and somatosensory cortices. It is unclear to what degree each site plays a role in establishing the different temporal patterns of photophobia across different disorders. Peptides such as calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide may play a role in photophobia at multiple levels of the visual and trigeminal pathways.CONCLUSION:
While our understanding of photophobia has greatly improved in the last decade, there are still unanswered questions. These answers will help us develop new therapies to provide relief to patients with primary headache disorders.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fotofobia
/
Cefaleas Primarias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Headache
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos