Evaluation of the Utility of in utero Treatment of Twin Anemia-Polycythemia Sequence.
Fetal Diagn Ther
; 38(3): 170-8, 2015.
Article
en En
| MEDLINE
| ID: mdl-25790745
ABSTRACT
OBJECTIVE:
The aim of this study is to evaluate the interest in the in utero treatment of twin anemia-polycythemia sequence (TAPS).METHODS:
The obstetrical and neonatal data on all cases of TAPS followed up in our institution between 2006 and 2013 were reviewed. Statistical analyses were conducted using Bayesian methods.RESULTS:
Twenty cases of TAPS were included. Laser therapy or intrauterine transfusion (IUT) was performed on the donor twin in 9 cases. Eleven cases were included in the 'nontreated' group (managed expectantly or diagnosed at birth). The gestational age at diagnosis was lower in the group with treated TAPS [difference (diff) = -22.20 days (-57.13, 14.28), probability (Pr) (diff >0) = 10.6%]. The rate of preterm premature rupture of membranes was higher in the group with treated TAPS [diff = 22.5% (-14, 57), Pr (diff >0) = 89%], but overall mortality was similar. The interval between diagnosis and delivery was longer [diff = 44.37 days (9.41, 77.90), Pr (diff >0) = 99.2%], the TAPS resolution rate was higher [diff = 49.9% (12, 81), Pr (diff >0) = 99.4%], and the neonatal transfusion rate was lower [diff = -30.5% (-60, 0), Pr (diff >0) = 2.6%] in the treated group.CONCLUSION:
In utero treatment for TAPS is associated with a higher resolution rate of TAPS and a longer time between diagnosis and birth, but overall mortality is the same as with expectant management.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Policitemia
/
Transfusión de Sangre Intrauterina
/
Coagulación con Láser
/
Transfusión Feto-Fetal
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Anemia
Límite:
Adult
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Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Fetal Diagn Ther
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
OBSTETRICIA
/
PERINATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Francia