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ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.
Junankar, Simon; Baker, Laura A; Roden, Daniel L; Nair, Radhika; Elsworth, Ben; Gallego-Ortega, David; Lacaze, Paul; Cazet, Aurélie; Nikolic, Iva; Teo, Wee Siang; Yang, Jessica; McFarland, Andrea; Harvey, Kate; Naylor, Matthew J; Lakhani, Sunil R; Simpson, Peter T; Raghavendra, Ashwini; Saunus, Jodi; Madore, Jason; Kaplan, Warren; Ormandy, Christopher; Millar, Ewan K A; O'Toole, Sandra; Yun, Kyuson; Swarbrick, Alexander.
Afiliación
  • Junankar S; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Baker LA; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Roden DL; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Nair R; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Elsworth B; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Gallego-Ortega D; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Lacaze P; Millennium Science Pty Ltd, 4 Miles Street, Mulgrave, Victoria 3170, Australia.
  • Cazet A; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Nikolic I; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Teo WS; The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
  • Yang J; The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
  • McFarland A; The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
  • Harvey K; The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
  • Naylor MJ; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia [3] Discipline of Physiology and Bosch Institute,
  • Lakhani SR; 1] UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4072, Australia [2] School of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia [3] Pathology Queensland, The Royal Brisbane and Women's Hospital, Herston, Queensland 4029, Australia [4]
  • Simpson PT; 1] UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4072, Australia [2] School of Medicine, The University of Queensland, Brisbane, Queensland 4072, Australia [3] QIMR Berghofer Medical Research Institute, Herston, Queensland 4029, Australia.
  • Raghavendra A; 1] UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4072, Australia [2] QIMR Berghofer Medical Research Institute, Herston, Queensland 4029, Australia.
  • Saunus J; 1] UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4072, Australia [2] QIMR Berghofer Medical Research Institute, Herston, Queensland 4029, Australia.
  • Madore J; 1] UQ Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4072, Australia [2] QIMR Berghofer Medical Research Institute, Herston, Queensland 4029, Australia.
  • Kaplan W; The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
  • Ormandy C; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
  • Millar EK; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] Department of Anatomical Pathology, South Eastern Area Laboratory Service, St George Hospital, Kogarah, New South Wales 2217, Australia [3] School of M
  • O'Toole S; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] Department of Anatomical Pathology, Sydpath, St Vincent's Hospital, Darlinghurst, New South Wales 2010, Australia [3] Sydney Medical School, University
  • Yun K; The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
  • Swarbrick A; 1] The Kinghorn Cancer Centre &Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia [2] St Vincent's Clinical School, Faculty of Medicine, UNSW, Kensington, New South Wales 2033, Australia.
Nat Commun ; 6: 6548, 2015 Mar 27.
Article en En | MEDLINE | ID: mdl-25813983
Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a putative mammary basal cell of origin. Using an ID4GFP knock-in reporter mouse and single-cell transcriptomics, we show that ID4 marks a stem cell-enriched subset of the mammary basal cell population. ID4 maintains the mammary stem cell pool by suppressing key factors required for luminal differentiation. Furthermore, ID4 is specifically expressed by a subset of human BLBC that possess a very poor prognosis and a transcriptional signature similar to a mammary stem cell. These studies identify ID4 as a mammary stem cell regulator, deconvolute the heterogeneity of BLBC and link a subset of mammary stem cells to the aetiology of BLBC.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre / Neoplasias de la Mama / ARN Mensajero / Proteínas Inhibidoras de la Diferenciación / Glándulas Mamarias Animales Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Australia
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre / Neoplasias de la Mama / ARN Mensajero / Proteínas Inhibidoras de la Diferenciación / Glándulas Mamarias Animales Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2015 Tipo del documento: Article País de afiliación: Australia