Cystine growth inhibition through molecular mimicry: a new paradigm for the prevention of crystal diseases.
Curr Rheumatol Rep
; 17(5): 33, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25874348
ABSTRACT
Cystinuria is a genetic disease marked by recurrent kidney stone formation, usually at a young age. It frequently leads to chronic kidney disease. Treatment options for cystinuria have been limited despite comprehensive understanding of its genetic pathophysiology. Currently available therapies suffer from either poor clinical adherence to the regimen or potentially serious adverse effects. Recently, we employed atomic force miscopy (AFM) to identify L-cystine dimethylester (CDME) as an effective molecular imposter of L-cystine, capable of inhibiting crystal growth in vitro. More recently, we demonstrated CDME's efficacy in inhibiting L-cystine crystal growth in vivo utilizing a murine model of cystinuria. The application of AFM to discover inhibitors of crystal growth through structural mimicry suggests a novel approach to preventing and treating crystal diseases.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cálculos Renales
/
Imitación Molecular
/
Cistinuria
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Rheumatol Rep
Asunto de la revista:
REUMATOLOGIA
Año:
2015
Tipo del documento:
Article