Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization.

Bhatia, Shilpa; Baig, Nimrah A; Timofeeva, Olga; Pasquale, Elena B; Hirsch, Kellen; MacDonald, Tobey J; Dritschilo, Anatoly; Lee, Yi Chien; Henkemeyer, Mark; Rood, Brian; Jung, Mira; Wang, Xiao-Jing; Kool, Marcel; Rodriguez, Olga; Albanese, Chris; Karam, Sana D

Bhatia, Shilpa; Baig, Nimrah A; Timofeeva, Olga; Pasquale, Elena B; Hirsch, Kellen; MacDonald, Tobey J; Dritschilo, Anatoly; Lee, Yi Chien; Henkemeyer, Mark; Rood, Brian; Jung, Mira; Wang, Xiao-Jing; Kool, Marcel; Rodriguez, Olga; Albanese, Chris; Karam, Sana D.

Afiliación

Bhatia S; Department of Radiation Oncology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Baig NA; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Timofeeva O; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Pasquale EB; Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.
Hirsch K; Department of Radiation Oncology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
MacDonald TJ; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Dritschilo A; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Lee YC; Georgetown University Hospital, Washington, DC, USA.
Henkemeyer M; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Rood B; Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jung M; Children's National Medical Center, Washington DC, USA.
Wang XJ; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Kool M; Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Rodriguez O; Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Heidelberg, Germany.
Albanese C; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Karam SD; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.

Oncotarget ; 6(11): 8929-46, 2015 Apr 20.

Article en En | MEDLINE | ID: mdl-25879388

Asunto(s)

Neoplasias Cerebelosas/patología; Meduloblastoma/patología; Proteínas de Neoplasias/fisiología; Receptor EphB1/fisiología; Animales; Proteínas de Ciclo Celular/biosíntesis; Proteínas de Ciclo Celular/genética; Línea Celular Tumoral; Movimiento Celular; Neoplasias Cerebelosas/enzimología; Neoplasias Cerebelosas/genética; Supervivencia sin Enfermedad; Fase G1; Humanos; Integrina beta1/biosíntesis; Integrina beta1/genética; Meduloblastoma/enzimología; Meduloblastoma/genética; Meduloblastoma/radioterapia; Ratones; Ratones Noqueados; Ratones Mutantes; Ratones Transgénicos; Proteínas de Neoplasias/deficiencia; Proteínas de Neoplasias/genética; Trasplante de Neoplasias; Fosforilación; Procesamiento Proteico-Postraduccional; Proteínas Proto-Oncogénicas pp60(c-src)/metabolismo; Interferencia de ARN; ARN Interferente Pequeño/genética; Tolerancia a Radiación; Receptor EphB1/deficiencia; Receptor EphB1/genética

Palabras clave

ATM; Eph; cell cycle; medulloblastoma; radiosensitization

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Cerebelosas / Receptor EphB1 / Meduloblastoma / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Oncotarget Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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